In the early years of the 1900's investigators began to discover cases of pellagra in insane asylums and started to explore the incidence of this malady in nonistitutionalized populaitons. The origins, causes, and effective treatments for this conditian were uncertain and subject to debate among physicians and medical researchers. Among the competing causal hypotheses were:
- eating too much or uncured corn
- microorganims carried by flies
- corn fungus
- side effects of syphilis
- infectious agents found in unsanitary living environments
Evidence was slowly emerging, that led some investigators to suspect that a poor diet might be responsible. By 1912, however, Dr. Edward Jenner Wood, chairman of the Pellagra Commission of the North Carolina, concluded that "insufficient nourishment" was not a cause. Five facts were known:
Because hookworm and roundworm infestations frequently accompanied outbreaks of pellagra, the previaling belief was that the disease was a result of toxic or infectious agents and was highly communicable.