Chemistry 250 Laboratory Schedule -- Fall 2009

Current Week in Lab	Hanson Lecture Website
Introduction to Organic Lab	Dasher Lecture Website
Organic Chemistry Websites	Scharrer Lecture Website
Synthesis and Use of Jacobsen's Salen(Co) Catalyst

Week 1 (8/31-9/4) All labs, except the Monday lab, will start next week.

• The Monday lab will meet on Friday of this week (1-5 pm)
  • Letter to Monday lab students
• Read the Introduction to Organic Lab handout

Week 2 (9/7-9/11) Safety, Lab Notebook, MSDS, and Unknowns

• Techniques: Melting Point, Refractometry,
  • Chapter 1: Safety First, Last, and Always
  • Chapter 2: Keeping a Notebook
  • Chapter 3: Interpreting a Handbook
  • Chapter 12: The Melting Point Experiment (We use the Mel-Temp apparatus)
  • Chapter 30: Refractometry

Week 3 (9/14-9/18) Preparation and Recrystallization of a Salt & Check-In

• Techniques: Recrystallization, Introduction to IR
  • Chapter 4: Jointware; Chapter 6: Other Interesting Equipment
  • Chapter 11: On Products
  • Chapter 13: Recrystallization
  • Chapter 34: Infrared Spectroscopy

Week 4 (9/21-9/25) Acid-Base Extraction

• Techniques: Extraction and Washing
  • Chapter 9: Clean and Dry; Chapter 10: Drying Agents
  • Chapter 15: Extraction and Washing
  • Chapter 22: The Rotary Evaporator

Week 5 (9/28-10/2) Running a Reaction: Preparation of an Imine

• Techniques: Reflux and Thin-Layer Chromatography
  • Chapter 17: And Now - Boiling Stones
  • Chapter 18: Sources of Heat (Focus on Heating Mantles)
  • Chapter 23: Reflux & Addition
  • Chapter 27: Chromatography: Some Generalities
  • Chapter 28: Thin-Layer Chromatography (You may skip the section on Preparation of TLC Plates)

Unknowns Report Due

Week 6 (10/5-10/9) Molecular Modeling on the Computer

• Techniques: Molecular Mechanics and Molecular Orbital Calculations
• Extraction Report Due in Lab this week.

Week 7 (10/12-10/16) Substitution and Elimination

• Techniques: Gas Chromatography (GC)
  • Chapter 32: Gas Chromatography
• Turn in copies of your notebook pages from the molecular modeling lab.

Week 8 (10/19-10/23) No Lab This Week (Fall Break on Monday & Tuesday)

Week 9 (10/26-10/30) Analysis of the Resolution of 1,2-Diaminocyclohexane and Preparation of Jacobsen's Salen(Co) Complex

• Techniques: Polarimetry
• Substitution and Elimination Report Due Friday, October, 30 in your lecture class.

Week 10 (11/2-11/6) Isolation of a Natural Product & Starting the Hydroytic Kinetic Resolution of an Epoxide Using Jacobsen's Salen(Co) Catalyst

• Techniques: Distillation
  • Chapter 19: Clamps and Clamping
  • Chapter 20: Distillation
• Progress Report on Jacobsen Catalyst Synthesis Due Friday, November 6 in your lecture class.

Week 11 (11/9-11/13) Hydrolytic Kinetic Resolution (HKR) of an Epoxide Using Jacobsen's Salen(Co) Catalyst -- Purification by Flash Chromatography

• Techniques: Flash Chromatography
  • Chapter 27: Chromatography: Some Generalities
  • Chapter 28: Thin-Layer Chromatography: TLC
  • Chapter 29: Wet-Column Chromatography
  • Natural Product Isolation Report Due in Lab this Week.

Week 12 (11/16-11/20) Analysis of the Products from the Hydrolytic Kinetic Resolution of an Epoxide

• Techniques: NMR, IR, Chiral GC, Chiral Shift Reagents
  • Chapter 35: Nuclear Magnetic Resonance (NMR)

Week 13 (11/24-11/28) No Lab -- Thanksgiving Break

Week 14 (12/1-12/5) Check-out, Clean-Up, Lab Final

• Final Jacobsen Report is due Friday, December 4, in your lecture class